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WhatsApp: +86 18221755073Genetic and biochemical analysis revealed a PKS-NRPS assembly line that activates 2S,3S-methylproline derived from l-isoleucine, followed by Knoevenagel condensation to construct the pyrrolizidine moiety.
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WhatsApp: +86 18221755073A review. Assembly line polyketide synthases (PKSs) are remarkable biosynthetic machines with considerable potential for structure-based engineering. Several types of protein …
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WhatsApp: +86 18221755073We mined the genome of a thermophilic fungus and activated the ucs gene cluster to produce UCS1025A at a high titer. Genetic and biochemical analysis revealed a PKS-NRPS …
WhatsApp: +86 18221755073Assembly-line polyketide synthases, such as the 6-deoxyerythronolide B synthase (DEBS), are large enzyme factories prized for their ability to produce specific and complex …
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WhatsApp: +86 18221755073Identification of assembly-line PKSs. Our approach for automated computational analysis of assembly-line PKSs is summarized in Figure 1.As of May 2013, the National …
WhatsApp: +86 18221755073Assembly line polyketide synthases (PKSs) are a large family of multifunctional enzymes responsible for synthesizing many medicinally relevant natural...
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WhatsApp: +86 18221755073UCS1025A is a fungal polyketide/alkaloid that displays strong inhibition of telomerase. The structures of UCS1025A and related natural products are featured by a tricyclic furopyrrolizidine connected to a trans …
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WhatsApp: +86 18221755073Request PDF | Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids | UCS1025A is a fungal polyketide/alkaloid that …
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